Detalhe da pesquisa
1.
Heme Detoxification in the Malaria Parasite: A Target for Antimalarial Drug Development.
Acc Chem Res
; 54(11): 2649-2659, 2021 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33982570
2.
THC shows activity against cultured Plasmodium falciparum.
Bioorg Med Chem Lett
; 54: 128442, 2021 12 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34763083
3.
Intrinsic fluorescence properties of antimalarial pyrido[1,2-a]benzimidazoles facilitate subcellular accumulation and mechanistic studies in the human malaria parasite Plasmodium falciparum.
Org Biomol Chem
; 18(42): 8668-8676, 2020 11 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-33078179
4.
Lapatinib, Nilotinib and Lomitapide Inhibit Haemozoin Formation in Malaria Parasites.
Molecules
; 25(7)2020 Mar 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-32235391
5.
Prediction Model for Antimalarial Activities of Hemozoin Inhibitors by Using Physicochemical Properties.
Antimicrob Agents Chemother
; 62(5)2018 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-29439979
6.
Evolution of Fitness Cost-Neutral Mutant PfCRT Conferring P. falciparum 4-Aminoquinoline Drug Resistance Is Accompanied by Altered Parasite Metabolism and Digestive Vacuole Physiology.
PLoS Pathog
; 12(11): e1005976, 2016 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-27832198
7.
Interplay between Plasmodium falciparum haemozoin and L-arginine: implication for nitric oxide production.
Malar J
; 17(1): 456, 2018 Dec 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-30522493
8.
Fe(III) Protoporphyrin IX Encapsulated in a Zinc Metal-Organic Framework Shows Dramatically Enhanced Peroxidatic Activity.
Inorg Chem
; 57(3): 1171-1183, 2018 Feb 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-29308888
9.
Shining new light on ancient drugs: preparation and subcellular localisation of novel fluorescent analogues of Cinchona alkaloids in intraerythrocytic Plasmodium falciparum.
Org Biomol Chem
; 15(3): 589-597, 2017 Jan 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-27785512
10.
Identification and deconvolution of cross-resistance signals from antimalarial compounds using multidrug-resistant Plasmodium falciparum strains.
Antimicrob Agents Chemother
; 59(2): 1110-8, 2015 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-25487796
11.
Optimization of a multi-well colorimetric assay to determine haem species in Plasmodium falciparum in the presence of anti-malarials.
Malar J
; 14: 253, 2015 Jun 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-26099266
12.
Bayesian models trained with HTS data for predicting ß-haematin inhibition and in vitro antimalarial activity.
Bioorg Med Chem
; 23(16): 5210-7, 2015 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25573118
13.
Antimalarial benzoheterocyclic 4-aminoquinolines: Structure-activity relationship, in vivo evaluation, mechanistic and bioactivation studies.
Bioorg Med Chem
; 23(17): 5419-32, 2015 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26264839
14.
N10,N11-di-alkylamine indolo[3,2-b]quinolines as hemozoin inhibitors: design, synthesis and antiplasmodial activity.
Bioorg Med Chem
; 23(7): 1530-9, 2015 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25725608
15.
Kojic acid derived hydroxypyridinone-chloroquine hybrids: synthesis, crystal structure, antiplasmodial activity and ß-haematin inhibition.
Bioorg Med Chem Lett
; 24(15): 3263-7, 2014 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24974345
16.
Molecular structures and solvation of free monomeric and dimeric ferriheme in aqueous solution: insights from molecular dynamics simulations and extended X-ray absorption fine structure spectroscopy.
Inorg Chem
; 53(20): 10811-24, 2014 Oct 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-25275882
17.
Synthesis, ß-haematin inhibition, and in vitro antimalarial testing of isocryptolepine analogues: SAR study of indolo[3,2-c]quinolines with various substituents at C2, C6, and N11.
Bioorg Med Chem
; 22(9): 2629-42, 2014 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24721829
18.
Exploring the modulatory influence on the antimalarial activity of amodiaquine using scaffold hybridisation with ferrocene integration.
Eur J Med Chem
; 271: 116429, 2024 May 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-38663284
19.
Discovery of antiplasmodial pyridine carboxamides and thiocarboxamides.
Int J Parasitol Drugs Drug Resist
; 25: 100536, 2024 Apr 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-38663046
20.
Blood-stage antimalarial activity, favourable metabolic stability and in vivo toxicity of novel piperazine linked 7-chloroquinoline-triazole conjugates.
Eur J Med Chem
; 264: 115969, 2024 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-38039787